Description
Product Characteristics:
Densin-180 is a synaptic transmembrane protein that is tightly associated with the postsynaptic density in CNS neurons and is postulated to function as a synaptic adhesion molecule. Densin-180 is a brain-specific momber of the O-sialoglycoprotein family which is highly concentrated at synapses along dendrites. The sequence of densin-180 contains 17 leucine-rich repeats, a sialomucin domain, an apparent transmembrane domain, and a PDZ (PSD-95, DIg, Z0-1) domain. The PDZ domain contributes to its binding to a-actinin. The intracellular portion of densin-180, CaMKIIa, interacts with a-actinin at distinct binding sites and, together, they form a ternary complex stabilized by multiple interactions.
Subcellular location: Cytoplasm, Cell membrane
Synonyms: Densin 180, Densin, Densin-180, densin180, DKFZp686I1147, KIAA1365, Lamin associated polypeptide 1, LAP 1, Leucine rich repeat containing 7, Leucine rich repeat containing protein 7, Leucine-rich repeat-containing protein 7,Lrrc 7, Lrrc7, LRRC7_HUMAN, MGC144918, OTTHUMP00000065336, OTTHUMP00000065337,OTTHUMP00000065338, Protein Lap 1, Protein lap1.
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